Estradiol enantate (EEn or E2-EN), also spelled estradiol enanthate and sold under the brand names Perlutal and Topasel among others, is an estrogen medication which is used in hormonal birth control for women. It is formulated in combination with dihydroxyprogesterone acetophenide (DHPA; algestone acetophenide), a progestin, and is used specifically as a combined injectable contraceptive. Estradiol enantate is not available for medical use alone. The medication, in combination with DHPA, is given by injection into muscle once a month.

Side effects of estradiol enantate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. Estradiol enantate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. It is an estrogen ester and a long-lasting prodrug of estradiol in the body.Because of this, it is considered to be a natural and bioidentical form of estrogen.

Estradiol enantate was first described by 1954, and was first studied in combination with DHPA as a combined injectable contraceptive in 1964.The combination was introduced for clinical use by the mid-1970s.Estradiol enantate is not available as a standalone medication (i.e., by itself without DHPA). The combination is available in Latin America and Hong Kong, and was also previously marketed in Spain and Portugal.

Estradiol Enanthate is a medication commonly used in hormone replacement therapy (HRT) for transgender women, also known as male-to-female (MTF) individuals. It belongs to a class of medications called estrogen hormones, which help to feminize the body and induce secondary female sex characteristics.

As an esterified form of estradiol, Estradiol Enanthate has a longer duration of action compared to other forms of estrogen, allowing for less frequent dosing. This medication is typically administered through intramuscular injection.


Dosage and administration: The dosage of Estradiol Enanthate varies depending on individual needs and goals. Typically, the initial dose is 5 to 10 milligrams (mg) injected intramuscularly every one to two weeks. However, this can be adjusted based on hormone levels, desired feminization effects, and any potential side effects.

 Monitoring hormone levels: Regular monitoring of hormone levels, including estradiol and testosterone, is important to ensure that therapeutic goals are being met and to adjust the dosage if necessary. Blood tests are typically conducted every 3 to 6 months initially and then less frequently once stable hormone levels are achieved.

Potential side effects: Like any medication, Estradiol Enanthate may have side effects. Common side effects include breast tenderness, changes in libido, mood swings, and injection site reactions. However, the occurrence and severity of side effects vary among individuals. If you experience any concerning side effects, it is important to inform your healthcare provider.