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Methrandoplex-20 does not react strongly with the androgen receptor, instead relying on activity not mediated by the receptor for its effects these include dramatic increases in protein synthesis, glycogenolysis and muscle strength over a short space of time. In high doses (30 mg or more per day), side effects such as gyndecomastia, high blood pressure, acne and male pattern baldness may begin to occur. The drug causes severe masculinising effect in women even at low doses. Without the administration of aromatase inhibitors, estrogenic effect will appear over time in men. Many users will combat the estrogenic side effects with Tamoxifen or clomid.